01
7-keto-Lithocholic acid (7-KLCA) 4651-67-6
Product Specification
Appearance: |
white crystalline powder |
Melting point: |
205 ° C |
Boiling point: |
545.9 ± 25.0 ° C (Predicted) |
Density: |
1.124 ± 0.06g/cm3 (Predicted) |
Storage conditions: |
Sealedindry, RoomTemperature |
Solubility: |
Dioxane (mild), DMSO (mild), methanol (mild) |
Form: |
Solid |
Acidity coefficient (pKa): |
4.76 ± 0.10 (Predicted) |
Water solubility: |
2.062mg/Lat25 |
description1
PRODUCT DESCRIPTION
3A-Hydroxy-7-oxo-5 β - cholic acid is a derivative of lithocholic acid, which is a bile acid derivative used as a TGR5 modulator. 3a-hydroxy-7-oxo-5 β - cholic acid, also known as 7-ketolithocholic acid or 7-oxolithocholic acid; White crystalline powder, odorless, insoluble in water, soluble in alcohol, 3a-hydroxy-7-oxo-5 β - cholic acid is an important intermediate for the preparation of obeticolic acid and also an important intermediate for the preparation of ursodeoxycholic acid.
3-hydroxy-7-oxo-5-cholic acid is an intermediate in organic synthesis and pharmaceutical research and development, and is an intermediate in the synthesis of the choleretic drug ursodeoxycholic acid.
Preparation: Goose deoxycholic acid can be oxidized with sodium hypochlorite to obtain high-purity 3a hydroxy-7-oxo-5 β - bile acid. The reaction temperature is controlled at -15 ° C, and acetic acid is used to adjust the acidity. Methanol is used as the solvent to prepare the crude 3a hydroxy-7-oxo-5 β - bile acid. The crude product is made into a barium salt, and then barium is removed. Finally, it is recrystallized from methanol and water to obtain high-purity 3a hydroxy-7-oxo-5 β - bile acid.