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Benfotiamine 22457-89-2 Vitamin B1 derivatives
Product Specification
Appearance: | White to light yellow crystalline powder |
Solubility: | Slightly soluble in water, very slightly soluble in methanol andethanol (95%), practically insoluble in n-heptane |
ldentification: | UV The maximum absorption occurs at 244 nm、HPLC Retention time of major peak in the chromatogram of samplesolution should correspond to that of the standard solution asobtained in the Related Substances by HPLC. |
Acidity: | 3.5~4.5 |
Clarity and color of solution: | It should not be darker than yellow No.1 standard colorimetricsolution |
Chloride: | ≤0.05% |
Sulfate: | ≤0.05% |
description1
PRODUCT DESCRIPTION
Phenylthiophene is a lipid soluble derivative of vitamin B1. Apart from its physical and chemical properties that differ from water-soluble vitamin B1, the structural difference lies in its open thiazole ring, which forms physiologically active vitamin B1 through closed-loop action in the body.
After ingestion of benzothiamine, the maximum blood drug concentration of vitamin B1 is about 5 times higher than that of vitamin B1 intake, the maximum bioavailability is about 3.6 times higher than that of vitamin B1 intake, and it is higher than other fat soluble vitamin B1 derivatives. Research on humans and animals has shown that compared to water-soluble forms of vitamins, the bioavailability and biological activity of phenylphosphothiamine are higher. Compared with vitamin B1, the peak and total concentration of vitamin B1 and its phosphate produced by phenylphosphothiamine are higher in plasma, whole blood, red blood cells, and tissues, and its plasma half-life is also longer. The relative bioavailability increased more significantly in muscle tissue (5-fold) and brain (25-fold), and also increased by 10-40% in other tissues such as liver and kidney.
Adults were given oral administration of thiamine diphosphate and thiamine hydrochloride to measure the total vitamin B1 levels in blood, as well as the increase in coenzyme type vitamin B1 (thiamine pyrophosphate) and free vitamin B1 levels. The results showed that compared with thiamine hydrochloride, thiamine diphosphate had the highest absorption in the digestive tract, maintained a high concentration of total vitamin B1 in blood, and had a high conversion rate of coenzyme type vitamin B1.