Bilirubin 635-65-4 Prevention and treatment of coronary heart disease

In addition to the natural bilirubin IX alpha, it also contains III alpha and XIII alpha isomers. The two vinyl groups on the pyrrole ring of IX alpha molecule are located in the medial and lateral positions, respectively. Under acidic conditions, they can form isomers III alpha or XIII alpha with both vinyl groups in the lateral position. The degree of isomerization varies depending on the type, concentration, and operation of the acid used for acidification in the production process. 

This product mainly comes from the reduction products of heme in hemoglobin after the disintegration of aging red blood cells. Bilirubin can be reduced to bilirubin through in vitro chemical reactions or biliverdin reductase. Bilirubin can bind to glycine, alanine, or histidine. Bilirubin is a strong endogenous antioxidant at normal serum concentrations. The molecular structure of bilirubin can have two types: ketone and alcohol. Due to the specific coiled structure of bilirubin, its hydrophobicity increases and it can enter the interior of lipid molecules. Bilirubin has an extended conjugated double bond system and active hydrogen atoms, which can prevent oxidation. The experiment shows that bilirubin can inhibit the oxidative modification of LDL (low density lipoprotein in blood) to a certain extent in vitro, which can inhibit and alleviate the formation of atherosclerosis caused by oxidative modification of LDL, so as to ultimately achieve the purpose of preventing and treating coronary heart disease.

Bilirubin is a major component of heme decomposition and the main pigment in bile. It serves as an antioxidant and an effective hydrogen peroxide scavenger, protecting cell membrane lipids from the oxidative effects of these reactive groups. Generally used for biochemical research, analytical chemistry, and synthesis of bezoar. It can also be used as an antioxidant to protect membrane phospholipids from oxidation by hydrogen peroxide free radicals, and can protect neurons from oxidative damage even at nanomolar concentrations. It is also used for the determination of artificial bovine bilirubin. Bilirubin has multiple pharmacological effects and is the main raw material for manufacturing artificial bezoar. Pharmacological experiments have shown that it has a good inhibitory effect on W256 tumor, and its inactivation rate and inhibition index against Japanese encephalitis virus are 1-1.5 times higher than those of deoxycholic acid and bile acid; It is also an effective therapeutic drug for liver diseases, with the ability to proliferate new cells without damaging liver tissue. It can treat diseases such as serum hepatitis and cirrhosis. In addition, bilirubin has sedative, sedative, antipyretic, and antihypertensive properties. Promote the regeneration of red blood cells and other functions.