Lithocholic acid (LCA) 434-13-9

Lithocholic acid is a type of bile acid that can dissolve fat for absorption.

Cholic acid is a secondary bile acid, also known as cholelithiasis, 3-hydroxycholic acid, lithocholic acid, 3-alkanoate, lithoic acid, 3-hydroxycholic acid, or lithocholic acid, found in the bile of higher vertebrates. The molecular structure of bile acids contains both hydrophilic and hydrophobic groups, so the stereochemistry of bile acids has both hydrophilic and hydrophobic properties, which gives bile acids strong interfacial activity. Through literature review, it was found that lithocholic acid has many pharmacological activities, such as inhibiting tumor growth, selectively killing breast cancer cells, and selectively inhibiting the activity of mammalian DNA polymerase.

Stone bile acid can kill glioma cells and is harmless to normal nerve cells. The specific principle of action is that low concentrations of stone bile acid (LCA) can make BE (2) - m17 and SK-n-MCIXC cells sensitive to hydrogen peroxide induced cell death. A certain concentration of LCA makes the primitive culture of human neuronal cells resistant to this type of cell death. LCA can not only achieve the killing of BE (2) - m17 and SK-n-MCIXC cells through the intrinsic pathway of cell death driven by mitochondrial outer membrane permeabilization and activation of initiator CASPASE-9, but also through the extrinsic pathway of cell death involving activation of initiator CASPASE-8. We can interpret these internal and external pathways of tumor cell apoptosis through the cascade reaction of cell apoptosis.

Stone bile acid can be used to synthesize stone bile acid adenosine.