01
NMN 1094-61-7 anti-aging
Product Specification
Appearance: |
White to slightly yellow crystalline powder |
Melting point: |
166 ° C (dec.) |
Storage conditions: |
-20 ° C |
Solubility: |
soluble in DMSO (slight heating), methanol (slight), water (slight) |
description1
PRODUCT DESCRIPTION
NMN,Full name: β - nicotinamide mononucleotide, also known as nicotinamide mononucleotide. Structurally, this molecule is composed of nicotinamide, ribose, and phosphate groups. A pH value of 3.0-4.0, it is a naturally occurring biologically active nucleotide that exists in various organisms and is also a cosmetic ingredient with a shelf life of 24 months. It is a key intermediate in the synthesis of coenzyme I - NAD+.
NMN is an inherent substance in the human body and is also abundant in some fruits and vegetables. As nicotinamide belongs to vitamin B3, NMN belongs to the category of vitamin B derivatives, which are widely involved in multiple biochemical reactions in the human body and closely related to immunity and metabolism.
NMN is also used in anti-aging research. Research has shown that β - NMN can also regulate insulin secretion and affect mRNA expression levels. β - NMN has broad application prospects in the field of medical treatment. β - nicotinamide mononucleotide is a product of the extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+intermediate. It improves glucose tolerance by restoring NAD+levels in HFD induced T2D mice. It also enhances liver insulin sensitivity and partially restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm through SIRT1 activation.
Preclinical studies have shown that NMN has a variety of pharmacological activities in heart and brain ischemia, Alzheimer's disease, type 2 diabetes and obesity caused by diet and age. As a precursor of NAD+, NMN mainly synthesizes NAD+in vivo to play a pharmacological role, all of which are related to the lack of NAD+.
Although NMN can be used for drug development, due to strict registration regulations and rigorous clinical trial basis, drug development for disease treatment or prevention requires considerable time and money. The β - nicotinamide mononucleotide products on the market are mainly developed in the form of health supplements, which can be used for anti-aging and antioxidant therapy. On the other hand, there are relatively few NMN products that combat skin aging, so the development in this area is quite innovative.