01
Trimebutine Maleate 34140-59-5
Product Specification
| Appearance: | White crystals or crystalline powder |
| Solubility: | Freely soluble in N,N-dimethylformamide and in acetic acid, solubel in acetonitrile, and slightly soluble in water and in ethanol(99.5) |
| Identification: | IR/UV Spectrum should match with that of standard |
| Melting point: | 131℃-135℃ |
| Heavy metals: | ≤10ppm |
| Arsenic: | ≤1ppm |
| Loss on drying: | ≤0.5% |
| Residue on ignition: | ≤0.1% |
| Single impurity: | ≤0.1% |
| Total impurity: | ≤0.5% |
| Appearance of solution: | Clear and colorless |
| Heavy metals: | ≤0.001% |
| Assay(HPLC): | 99.0%-101.0% |
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PRODUCT DESCRIPTION
Trimebutine maleate is a gastrointestinal motility regulator that is different from cholinergic and anti dopamine drugs, and has a bidirectional regulatory effect on gastrointestinal smooth muscle. It can inhibit the release of norepinephrine, and in cases of gastrointestinal hyperfunction, this product mainly acts on the K receptor, thereby improving the hyperkinetic state. Therefore, it is commonly used clinically for gastrointestinal symptoms caused by chronic gastritis, such as abdominal bloating, abdominal pain, and belching, and is also used for irritable bowel syndrome.
Trimebutine Maleate 1. Used for gastrointestinal symptoms caused by chronic gastritis (such as abdominal bloating, abdominal pain, belching, etc.). 2. Used for irritable bowel syndrome. 3. Used for the recovery of postoperative intestinal function. 4. Used for barium enema examination, it can accelerate the process of barium enema examination.
This product is a gastrointestinal spasmolytic drug that has a strong relaxing effect on the smooth muscles of the gastrointestinal tract and can alleviate spasms caused by various reasons. The characteristics of its action are as follows: 1. This medicine can inhibit the permeability of K, cause depolarization, and thus cause contraction (increased movement). 2. Acting on adrenergic receptors, inhibiting the release of norepinephrine, thereby increasing motor rhythm. 3. Inhibit the permeability of Ca2, causing relaxation (reduced movement). 4. It acts on the cholinergic K receptor, inhibits acetylcholine release, and thus improves hyperkinesia. Therefore, this medicine can directly act on the smooth muscle of the digestive tract, regulate and improve the abnormal state of gastrointestinal motility rhythm, adjust gastric motility rhythm, and improve gastric excretion function; Improve digestive system symptoms such as bloating and abdominal pain associated with chronic gastritis; Adjust intestinal motility rhythm and improve intestinal motility status; Improve digestive system symptoms such as loss of appetite, abdominal ringing, diarrhea, and constipation associated with irritable bowel syndrome.